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「Orthodontic treatment in the mixed dentition period is associated with systematic professional control and by the age of 15 years results in two-fold reduction in the intensity of caries and periodontal disease, proper detection of poor hygiene and the lower prevalence of abnormal positioning of the teeth (crowding and misalignment of teeth) and the improvement of dental arches ratio (completely eliminating cross-bite).」

「Implants were connected to lateral incisors with provisional restorations, and orthodontic treatment was initiated following digital set-ups incorporating implants into the overall strategy.」

「After performing cause-related therapy, periodontal regenerative surgery, pre-orthodontic posterior implant placement, and orthodontic treatment involving anterior implant placement with papilla reconstruction, the patient achieved full-mouth rehabilitation and improvement of dental and smile esthetics.」

「Periodontal disease often results in severely bony defects around the teeth and leads to eventual extraction.」

「It has shown significant advantages in the orthodontic treatment of periodontal disease, the orthodontic treatment of temporomandibular joint disorder (TMD), integrated approaches with dental implant restoration, and the combined treatment of orthodontics and orthognathic surgery.」

「Periodontal, orthodontic, and prosthodontic treatments are extremely useful to improve function and stable periodontal tissue for generalized periodontitis.」

「Changes in periodontal disease, orthodontic treatment, accidental damage to anterior teeth, tooth surface loss and enamel defects, are also summarised.」

「The authors carefully placed implants in a position in the maxillary molar region that would ensure an appropriate anterior dental relationship after orthodontic treatment.」

「Since 2000 case reports illustrate that improved oral care, orthodontic treatment, and dental implants under local or general anaesthetic can improve the quality of life for people with DS.」

「Dental implants are regularly placed in patients with a history of periodontitis, even though peri-implant tissues are susceptible to the same host-modulated plaque-induced factors that initiate and sustain periodontitis.」

「Visiting a dentist can easily evoke strong fear reactions and acute anxiety in children.」

「To investigate the association of maternal anxiety disorders with the occurrence of dental fear in children aged 24-36 months.」

「Parents with high anxiety appeared to negatively affect their children's behavior.」

「Childhood dental fear and anxiety may persist into adulthood.」

「Using Venham's clinical rating scale, Venham's picture test, parental stress questionnaire and recall questionnaire, the efficacy of the Camouflage Syringe to reduce dental fear and anxiety ranged from 82% to 97% for various outcomes and from 60% to 100% for prevention of related adverse outcomes.」

「To systematically review trials on the effect of nonpharmacologic interventions in behavior, anxiety, and pain perception in children undergoing dental treatment.」

「This qualitative research, using You-Tube as a platform, aimed to explore the public's perspectives on management of dental fear and anxiety (DFA) in pediatric patients.」

「The study highlights the need to enhance training in emotional management and alternative behavioral management techniques to prevent future trauma and reduce the likelihood that children will avoid dental care due to anxiety.」

「Child dental anxiety is a prevalent issue in the field of pediatric dentistry.」

「Oral health in children is additionally burdened with the presence of dental fear and anxiety (DFA).」

「This systematic review aimed to evaluate the available scientific evidence concerning the effects of topical fluoride treatment on the bond strength of pit and fissure sealants.」

「Comparative Analysis of Penetrability and Adaptability of Different Fluoride-releasing Pit and Fissure Sealants: An In Vitro Study.」

「The aim was to systematically evaluate the cost-effectiveness of pit and fissure sealants (PFSs) compared with that of fluoride varnishes (FVs) in dental caries prevention.」

「To evaluate the effect of nano-hydroxyapatite (nanoHAP) incorporation on fluoride-releasing ability, penetration, and adaptation of a pit and fissure sealant.」

「Pit and fissure sealants (PFSs) are the most effective preventive materials in dentistry.」

「The questionnaire includes questions pertaining to knowledge and practices toward pit and fissure sealants, fluoride application, and dental visits.」

「Children in the control group were treated with pit and fissure sealant for prevention of caries, while children in the combined group were treated with sodium fluoride tooth protector combined with pit and fissure sealant for caries prevention.」

「Pit and fissure sealants are plastic materials that are used to seal deep pits and fissures on the occlusal surfaces of teeth, where decay occurs most often in children and adolescents.」

「However, current clinical practices rely on sealants that lack the ability to release and recharge fluoride ions.」

「Incorporation of fluoride in pit and fissure sealants has been found to reduce initiation and progression of pit and fissure caries.」

「To ensure the harmonious appearance of the restoration and the natural tooth and to obtain the ideal hard and soft tissue structure, clinicians should have a clear understanding of the factors that influence the success of aesthetics and apply different technique accordingly.」

「Due to the excellent restoration of masticatory function, satisfaction on aesthetics and other superiorities, dental implants represent an effective method to resolve tooth losing and damaging.」

「This case illustrates that dental implant restoration in the anterior esthetic zone can effectively address functional and esthetic challenges, leading to high patient satisfaction with the final restoration's natural appearance.」

「Improving the aesthetic outcome of dental implants, especially in the anterior maxillary region, presents a considerable clinical challenge.」

「Conclusion : The use of dental implants to rehabilitate the edentulous cleft area is an excellent option.」

「Although the aesthetics are not equivalent to that of dental implants in normal patients, patient satisfaction is still satisfactory in patients with dental implants in bone-grafted regions of cleft lip and palate.」

「The primary objective of the present systematic review is to test the hypothesis - the revision of the complexity of the extraction sockets morphology classifications will reveal the most important parameters for implant aesthetic and functional success in case of immediate dental implant placement in aesthetic zone.」

「Implant-supported full-mouth rehabilitation has emerged as an advanced solution, leveraging strategically placed dental implants to support fixed prostheses that mimic natural teeth in appearance and function.」

「Currently, the restoration of missing teeth by means of dental implants is a common treatment method in dentistry.」

「Since then, significant advances in dental implant technology have resulted in improved function and cosmetic appearance.」

「There was no significant difference in gender, age, implant, cause of tooth loss, history of hypertension, drinking history, implant diameter, implant length and bone increment surgery between good and poor groups(P＞0.05).」

「A patient who is interested in replacing missing teeth may be a candidate for dentures, implants, or a combination of these.」

「Modified oral implant restoration for maxillary anterior tooth loss can effectively enhance restoration outcomes, improve dental aesthetics, and promote better masticatory function and patient satisfaction.」

「While dental implants are increasingly becoming the choice of replacement for missing teeth, the impediments associated with them are progressively emerging too.」

「The role of the total lower denture is not only to replace the missing teeth but also to provide the substitute for a range of supporting tissues which have diminished due to the process of resorption, to re-establish the original relations in the region ofjaw complex, to support the surrounding soft tissues which have lost their natural support, and, moreover, to be unobtrusive and discrete substitution of lost functions.」

「There are various options to replace the missing teeth, such as removable dentures, fixed crown and bridge prostheses, and resin-retained bridges.」

「In part 2 of this series, we look at the clinician's role in replacing multiple missing teeth and the associated soft tissues and bone, following severe forms of trauma.」

「Dental implants are being utilized by numerous dentists to replace missing teeth by restoring the function of teeth without compromising the aesthetics.」

「Dental implantation has emerged as an efficient substitute for missing teeth, which is essential for restoring oral function and aesthetics.」

「The benefits of choosing fixed partial dentures (FPD) or dental implants were judged to be aesthetics (41.1%) and the feel of one's own teeth (40.1%).」

「According to data provided by the World Health Organization (WHO), malocclusions represent the third most widespread oral health problem, after dental caries and periodontal diseases.」

「They result in both quantitative and qualitative changes in dental plaque, exposing orthodontic patients to dental caries and periodontal diseases.」

「In the studied society, oral health and oral care skills are given less importance, as evidenced by high rates of periodontal diseases, caries, and filled teeth.」

「Orthodontic treatment has become increasingly popular due to its benefits in improving facial and smile aesthetics, self-esteem and the function of the stomatognathic apparatus.」

「It has shown significant advantages in the orthodontic treatment of periodontal disease, the orthodontic treatment of temporomandibular joint disorder (TMD), integrated approaches with dental implant restoration, and the combined treatment of orthodontics and orthognathic surgery.」

「Fixed appliances, functional devices and, more recently, clear aligners have been associated with several oral health conditions, including enamel demineralization, dental caries, gingivitis, periodontitis and root and bone resorption.」

「The aim of this study was to determine the relationship of orthodontic malocclusion with periodontal status, dental caries, and sociodemographic status.」

「The patient was treated with clear aligners, which effectively controlled the strength and direction of orthodontic forces after 3 months of systematic periodontal treatment.」

「This study indicated a positive correlation between dental caries and periodontitis clinically, while the two disease-associated pathogens were antagonistic.」

「Other data collected included clinically assessed oral health (dental caries and periodontal disease experience) and self-rated dental appearance, OHRQOL, life satisfaction, and personality traits.」

「Recently, MMP-2 was also considered to be an appropriate therapeutic target for prevention of periodontal disease progression.」

「Periodontal diseases are inflammatory diseases caused by oral pathogens around the periodontal supporting tissues, leading to systemic and chronic inflammatory conditions.」

「Periodontitis are infectious diseases characterized by immune-mediated destruction of periodontal supporting tissues and tooth loss.」

「Periodontitis, a bacterial infection leading to the destruction of tooth-supporting tissues, is primarily driven by elevated levels of subgingival microorganisms.」

「Periodontal diseases comprise a wide range of inflammatory conditions that affect the supporting structures of the teeth (the gingiva, bone and periodontal ligament), which could lead to tooth loss and contribute to systemic inflammation.」

「Cytokine networks established in diseased periodontal tissues are extremely complex, and substances regulating immuno-inflammatory reactions and signaling pathways, in addition to traditional periodontal treatment, could potentially be targeted as an approach for prevention and treatment of periodontal diseases.」

「Chronic periodontitis is an infectious disease resulting in inflammation within the supporting tissues of the teeth, progressive attachment loss, and bone loss.」

「Approximately 9 out of 10 adults have some form of periodontal disease, an infection-induced inflammatory disease of the tooth-supporting tissues.」

「Although the current treatment of periodontal disease can achieve good control of inflammation, it is difficult to regenerate the periodontal supporting tissues to achieve a satisfactory therapeutic effect.」

「According to the new classification proposed by the recent 2017 World Workshop on Periodontal and Peri-implant Diseases and Conditions, periodontitis, necrotizing periodontal diseases, periodontitis as a manifestation of systemic diseases, and systemic diseases or conditions affecting the periodontal supporting tissues, are considered as separate entities.」

「Outcome measures were: changes in the bucco-lingual/palatal width of alveolar ridge, changes in the vertical height of the alveolar ridge, complications, the need for additional augmentation prior to implant placement, aesthetic outcomes, implant failure rates, peri-implant marginal bone level changes, changes in probing depths and clinical attachment levels at teeth adjacent to the extraction site, and complications of future prosthodontic rehabilitation.」

「Outcome measures were: changes in the bucco-lingual/palatal width of alveolar ridge, changes in the vertical height of the alveolar ridge, complications, the need for additional augmentation prior to implant placement, aesthetic outcomes, implant failure rates, peri-implant marginal bone level changes, changes in probing depths and clinical attachment levels at teeth adjacent to the extraction site, and complications of future prosthodontic rehabilitation.」

「A patient who is interested in replacing missing teeth may be a candidate for dentures, implants, or a combination of these.」

「Eleven months after the dental implant surgery, a complete upper denture and a mandibular gingival ceramometal-casting crown were fitted.」

「Both implant and implant-natural tooth are effective in dental restoration, and implant-natural tooth restoration has good short-term efficacy, while bone mineral density loss, diabetes mellitus, smoking history, sulcus bleeding index≥2 and periodontal probe depth>3mm are the risk factors of implant failure.」

「The osseointegration process is characterized by a predictable sequence of healing events that encompass the formation of woven bone, parallel fibers, and lamellar bone and result in fully functional bone that will remodel throughout life.」

「Dental implants continue to increase in popularity as a method of replacing missing or failing teeth and, in doing so, this increased prevalence is likely to present as a range of scenarios for the general dental practitioner and dental hygienist, whether they have an interest in the field or not.」

「A dental implant is used to replace a missing tooth.」

「Due to the widespread acceptance of dental implants, interest in bone reconstruction for the oral cavity has increased dramatically over the past decade.」

「Various treatment approaches for restoring missing teeth are being utilized nowadays by using artificial dental crowns/bridges or the use of dental implants.」

「The proposed method showed the promising outlook for dental implant-supported restoration in difficult anatomical conditions.」

「Titanium is widely acknowledged as the "gold standard" for dental implants because of its superior biocompatibility and osseointegration capabilities.」

「In view of the recent progress in the field of oral implant, the factors affecting the aesthetic outcome of implant treatment were discussed including neck design of implant, design of customized abutment, tissue regeneration and gingival papilla height, so as to provide clinical reference to improving the aesthetic outcome of oral implant treatment. 除恢复咀嚼功能外，稳定良好的美学效果已成为口腔种植治疗的重要目标。临床医师需要清晰了解影响美学成功的因素，掌握相应的技术要点，从而保证修复义齿与天然牙的协调美观，获得理想的软硬组织结构。本文针对目前口腔种植领域的新进展，从种植体的颈部设计、个性化基台制备、组织增量以及龈乳头高度等方面，对影响口腔种植美学效果的相关因素进行阐述和讨论，为提高口腔种植修复治疗的美学效果提供参考。.」

「Conclusion : The use of dental implants to rehabilitate the edentulous cleft area is an excellent option.」

「Afterwards, a dental implant was placed followed by a connective tissue graft and immediate provisionalization of the crown.」

「To restore intraoral function and improve facial appearance, plastic surgeons transplanted a rib into the maxillary sinus while dental surgeons simultaneously inserted 5 dental implants.」

「When dental implants are malpositioned in relation to the adjacent teeth and alveolar bone or in an excessive buccal or lingual position, the final prosthesis rehabilitation impairs the peri-implant health of the gingival tissues and the aesthetics of the patient.」

「The socket shield technique presents a viable alternative for immediate dental implant placement in the esthetic zone.」

「Dental implants are connected to the alveolar bone by osseointegration.」

「Aesthetics of peri-implant soft tissues should be improved in the future.」

「Clear aligner therapy has expanded substantially in mixed dentition, yet the boundaries of clinical predictability across indications, movement types, and growth stages remain incompletely defined.」

「To analyse through a systematic review the effectiveness of clear aligners by assessing: (a) predictability of clear aligners and (b) treatment outcome comparison of clear aligner therapy with fixed appliance therapy.」

「The content of the guidelines is based on monographs and literatures on the clear aligner orthodontic treatment in the past five years, and the clinical consensus of all the members of Expert Group for Writing Project of Clear Aligner Technology.」

「"Guidelines for clear aligner orthodontic treatment (2021)" proposes clinical treatment recommendations in terms of practitioner requirements, clinical risks, diagnosis, treatment plan, and common clinical strategies for the orthodontic clear aligners technology.」

「An internet search reveals at least 27 different clear aligner products currently on offer for orthodontic treatment.」

「Proper selection of cases and reasonable design in clear aligner treatment are expected to obtain tooth alignment, good intercuspation, normal overbite and overjet, periodontal health, parallel roots, and to achieve the goal of aesthetic, functional, stable, and healthy orthodontic treatment. 术者诊断设计不当、矫治技术应用失误、正畸治疗后的复发以及患者依从性较差无法配合矫治等原因可导致患者对矫治结果不满意，寻求二次矫治。此类患者通常已减数，或伴牙周、关节、牙体或缺牙等问题，常需多学科联合治疗，二次矫治难度较大，可选方案受限。无托槽隐形矫治舒适美观，具备数字化精准化程度高、可个性化排牙模拟矫治后终末状态等特点，使其在失败病例的二次矫治中具有一定优势。本文通过展示无托槽隐形矫治在二次矫治病例中的应用实例，对矫治设计和监控细节进行讨论和总结。建议医师在接诊前利用无托槽隐形矫治难度评估工具对患者情况进行评估，接诊自身诊疗能力范围内的病例，以获得满意的矫治疗效。无托槽隐形矫治技术治疗减数病例的成功关键在于诊断正确，选对病例。在方案设计上，二次矫治应注意前牙转矩的恢复，利用推磨牙向后获得间隙，做好垂直向控制，改善后牙咬合关系。在无托槽隐形矫治中正确选择、谨慎纳入、合理设计，有望在二次矫治的疑难病例中获得牙排列整齐、尖窝交错、覆(牙合)覆盖正常、牙周健康、牙根平行的矫治效果，达到美观、功能、稳定、健康的矫治目标。.」

「The study, based on the modified Delphi method, collected the opinion of experts, comparing it with the scientific literature to evaluate the potential and limitations of orthodontic aligners, obtaining 47 consensus statements related to biomechanics and extraclinical factors.」

「Clear aligner therapy (CAT) has rapidly evolved as a preferred orthodontic treatment option due to its aesthetic appeal, comfort, and removability.」

「Background and Objectives: Recent advances in dentistry include microbiological and metabolomic analyses, which have the potential to improve the understanding of oral microbiome-host imbalances during orthodontic treatment.」

「The concept of using clear aligners as a means of achieving tooth movement has increased in popularity among both patients and clinicians alike.」