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「Included were studies of patients with permanent immature or mature teeth and pulp necrosis with or without signs of apical periodontitis (P) comparing ETE (I) with calcium hydroxide apexification, apical plug and root canal treatment (C) in terms of tooth survival, pain, tenderness, swelling, need for medication (analgesics and antibiotics), radiographic evidence of reduction in apical lesion size, radiographic evidence of normal periodontal ligament space, function (fracture and restoration longevity), the need for further intervention, adverse effects (including exacerbation, restoration integrity, allergy and discolouration), oral health-related quality of life (OHRQoL), presence of sinus tract and response to sensibility testing (O).」

「Subsequent endodontic treatment comprised pulp extirpation and root canal filling, followed by periodontal treatment consisting of scaling and root planing.」

「Despite successful root canal treatment, if the majority of bone support has been lost from periodontitis, the tooth may have a poor prognosis.」

「Clinical Relevance: This study provides clinically relevant insight into multiple prognostic factors that influence the outcome of primary root canal treatment in teeth with periapical lesions, including patient-related, tooth-related, and procedural variables.」

「Comprehensive case assessment, evaluation of all endodontic options, and risk assessment for caries and periodontal disease are always necessary when choosing the optimal treatment for a patient when initial root canal treatment has failed to heal.」

「Ten patients with abnormal pulp test results and deep probing depth derived from primary periodontal disease with secondary endodontic involvement were included.」

「In this clinical case, a 44-year-old male presented with primary periodontal disease with secondary endodontic involvement in his lower right canine because of aggressive periodontitis.」

「Chi-square and multivariable logistic regression analyses were performed to investigate associations with risk factors such as gender, tooth type, root canal treatment adequacy, final restoration status, dental caries, and periodontal disease.」

「As predicted by model one, the probability of absence of periapical lesion 2 years after endodontic treatment was 90% in pulpitis teeth with sever root-canal curvature and adequate root canal fillings, but 51% in teeth with apical periodontitis.」

「Objective: To report a rare case of pulp space tissue growth in a mature mandibular molar with severe endo-periodontal involvement after conservative endodontic treatment and to discuss the possible biological explanations, including regeneration and granulation tissue healing.」

「In case 1, a 45-year-old male patient received root canal treatment because of a cracked mandible right first molar with periapical lesions.」

「Under specific conditions, only the diseased part of the tooth can be extracted after an endodontic treatment.」

「Endodontic treatment quality significantly influenced periapical lesion development, lesion size, relationship between root and lesion, and bone destruction location (p < 0.05).」

「Unfortunately, studies have shown that this regimen only temporarily delays the progression of periodontal disease and does not prevent further tooth loss and bone destruction in the long term.」

「The aim of the study is to report clinical outcomes of autogenous tooth transplantation (ATT) of fully developed third molars following the extraction of periodontally hopeless teeth as a part of the treatment of a stage III, grade C, molar-incisor pattern (MIP) periodontitis case.」

「This report presents a case of successful ATT of a maxillary right third molar for replacement of mandibular right second molar with a concomitant endodontic-periodontal disease.」

「Patients were excluded if they met any of the following criteria: poor oral hygiene, inadequate mesio-distal space for implant placement, presence of periodontal disease, smoking, an American Society of Anesthesiologists (ASA) score of ≥II, or a vertical bony defect of less than 5 mm in the labial socket wall after tooth extraction.」

「This report presents a case of an endodontic-periodontal lesion in a tooth that was successfully treated by root canal treatment.」

「The treatment protocol comprised: 1) supra/sub-gingival instrumentation (Step Ⅰ-Ⅱ); 2) periodontal regenerative surgery using enamel matrix derivative (EMD) alone or combined with a bone graft and membrane (Step Ⅲ); 3) orthodontic treatment initiated 8-12 months post-surgery to correct malposition (Step R); and 4) tailored supportive periodontal care (SPC) (Step Ⅳ).」

「Intentional replantation has become the last possible method to preserve natural teeth for advance periodontitis with signs of tooth extraction.」